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NKD2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IF, IHC-P, WB, E |
|---|---|
| Primary Accession | Q969F2 |
| Other Accession | NP_149111.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50055 Da |
| Antigen Region | 366-393 aa |
| Gene ID | 85409 |
|---|---|
| Other Names | Protein naked cuticle homolog 2, Naked-2, hNkd2, NKD2 |
| Target/Specificity | This NKD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-393 amino acids from the C-terminal region of human NKD2. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NKD2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKD2 |
|---|---|
| Function | Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. |
| Cellular Location | Cell membrane. Cytoplasm. Cytoplasmic vesicle |
| Tissue Location | Expressed in kidney, lung, pancreas and spleen. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
References
Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)
Ding, W., et al. Proc. Natl. Acad. Sci. U.S.A. 105(36):13433-13438(2008)
Li, C., et al. Mol. Biol. Cell 18(8):3081-3093(2007)
Adamowicz, M., et al. Genes Chromosomes Cancer 45(9):829-838(2006)
Li, C., et al. Proc. Natl. Acad. Sci. U.S.A. 101(15):5571-5576(2004)
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