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JAG1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | P78504 |
| Other Accession | Q63722, Q9QXX0, NP_000205.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 133799 Da |
| Antigen Region | 1122-1150 aa |
| Gene ID | 182 |
|---|---|
| Other Names | Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1 |
| Target/Specificity | This JAG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1122-1150 amino acids from the C-terminal region of human JAG1. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | JAG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JAG1 |
|---|---|
| Synonyms | JAGL1 |
| Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane |
| Tissue Location | Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
References
Foldi, J., et al. J. Immunol. 185(9):5023-5031(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kerns, D., et al. Schizophr. Res. 120 (1-3), 150-158 (2010) :
Siar, C.H., et al. Eur. J. Med. Res. 15(4):180-184(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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