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Maspin Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IF - Maspin Antibody (Center) AP12083c
    Confocal immunofluorescent analysis of Maspin Antibody (Center)(Cat#AP12083c) with A2058 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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  • WB - Maspin Antibody (Center) AP12083c
    Western blot analysis of lysate from Hela cell line,using Maspin Antibody (Center)(Cat. #AP12083c).AP12083c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane.
    detail
  • IHC-P - Maspin Antibody (Center) AP12083c
    Maspin Antibody (Center) (Cat. #AP12083c)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Maspin Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF, IHC-P, E
Primary Accession P36952
Other Accession P70124, NP_002630.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42100 Da
Antigen Region 94-123 aa
Additional Information
Gene ID 5268
Other Names Serpin B5, Maspin, Peptidase inhibitor 5, PI-5, SERPINB5, PI5
Target/Specificity This Maspin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human Maspin.
Dilution IF~~1:10~50
WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMaspin Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINB5
Synonyms PI5
Function Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Cellular Location Secreted, extracellular space.
Tissue Location Normal mammary epithelial cells.
Research Areas
Citations ( 0 )

Background

SERPINB5 is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

References

Kim, J., et al. Tumour Biol. 31(5):471-476(2010)
Juengel, E., et al. World J Urol 28(4):465-471(2010)
Besgen, P., et al. J. Immunol. 184(9):5392-5402(2010)
Fung, C.L., et al. Histopathology 56(3):319-330(2010)
Adim, S.B., et al. World J Surg Oncol 8, 22 (2010) :

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$ 365.00
$ 140.00
Cat# AP12083c
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