GGH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IF, IHC-P, WB, E |
---|---|
Primary Accession | Q92820 |
Other Accession | NP_003869.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 35964 Da |
Antigen Region | 229-256 aa |
Gene ID | 8836 |
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Other Names | Gamma-glutamyl hydrolase, Conjugase, GH, Gamma-Glu-X carboxypeptidase, GGH |
Target/Specificity | This GGH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-256 amino acids from the C-terminal region of human GGH. |
Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GGH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GGH (HGNC:4248) |
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Function | Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. |
Cellular Location | Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq].
References
Adjei, A.A., et al. J Thorac Oncol 5(9):1346-1353(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Organista-Nava, J., et al. Leuk. Res. 34(6):728-732(2010)
Figueiredo, J.C., et al. Cancer Causes Control 21(4):597-608(2010)
Dervieux, T., et al. Pharmacogenet. Genomics (2009) In press :
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