DOK3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q7L591 |
Other Accession | NP_079148.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53288 Da |
Antigen Region | 293-321 aa |
Gene ID | 79930 |
---|---|
Other Names | Docking protein 3, Downstream of tyrosine kinase 3, DOK3 |
Target/Specificity | This DOK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human DOK3. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DOK3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DOK3 |
---|---|
Function | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). |
Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side |
Tissue Location | Expressed in spleen.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity).
References
Berger, A.H., et al. Nat. Genet. 42(3):216-223(2010)
Senis, Y.A., et al. J. Thromb. Haemost. 7(10):1718-1726(2009)
Honma, M., et al. Genes Cells 11(2):143-151(2006)
Robson, J.D., et al. Mol. Cell. Biol. 24(6):2332-2343(2004)
Favre, C., et al. Genes Immun. 4(1):40-45(2003)
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