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IL17B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IHC-P, E |
|---|---|
| Primary Accession | Q9UHF5 |
| Other Accession | NP_055258.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20437 Da |
| Antigen Region | 39-66 aa |
| Gene ID | 27190 |
|---|---|
| Other Names | Interleukin-17B, IL-17B, Cytokine Zcyto7, Interleukin-20, IL-20, Neuronal interleukin-17-related factor, IL17B, IL20, NIRF, ZCYTO7 |
| Target/Specificity | This IL17B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human IL17B. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IL17B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL17B |
|---|---|
| Synonyms | IL20, NIRF, ZCYTO7 |
| Function | Stimulates the release of tumor necrosis factor alpha and IL- 1-beta from the monocytic cell line THP-1. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies.
References
Koskinen, L.L., et al. Tissue Antigens 74(5):408-416(2009)
Wang, X., et al. Ann. Otol. Rhinol. Laryngol. 115(6):450-456(2006)
Ryan, A.W., et al. Tissue Antigens 65(2):150-155(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Moore, E.E., et al. Neuromuscul. Disord. 12(2):141-150(2002)
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