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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > OTOP1 Antibody (Center)
OTOP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q7RTM1 |
| Other Accession | Q7M734, Q80VM9, NP_819056.1 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67353 Da |
| Antigen Region | 360-388 aa |
| Gene ID | 133060 |
|---|---|
| Other Names | Otopetrin-1, OTOP1 |
| Target/Specificity | This OTOP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human OTOP1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OTOP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTOP1 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19656} |
|---|---|
| Function | Proton-selective ion channel (PubMed:29371428, PubMed:36266567). Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively. Sour taste receptor, which carries inward currents in response to extracellular acidification (By similarity). Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells (PubMed:37798269). NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel (PubMed:37798269). Might also participate in alkaline sensation. Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium. May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)- dependent manner and promote an influx of Ca(2+) in response to ATP. Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration. In obesity, may attenuate adipose tissue inflammation, through the negative regulation of IFNG signaling, hence may play an adaptive role in the maintainance of metabolic homeostasis. Following alkali activation, may also be permeable Na(+), K(+), Cs(+) and Li(+) (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7ZWK8}. Cell projection, microvillus {ECO:0000250|UniProtKB:Q80VM9}. Note=Found in the gelatinous membrane overlying the inner ear macular epithelium Also detected in the apical microvilli in inner ear supporting cells {ECO:0000250|UniProtKB:Q80VM9} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
OTOP1 is required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity).
References
Hurle, B., et al. Hum. Mol. Genet. 12(7):777-789(2003)
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$ 365.00
$ 140.00
Cat# AP11995c
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