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TUBB2B Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - TUBB2B Antibody (N-term) AP11940a
    All lanes : Anti-TUBB2B Antibody (N-term) at 1:4000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: MDA-MB-231 whole cell lysate Lane 4: K562 whole cell lysate Lane 5: Mouse brain tissue lysate Lane 6: Mouse cerebellum tissue lysate Lane 7: PC-12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 50 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • IHC-P-Leica - TUBB2B Antibody (N-term) AP11940a
    Immunohistochemical analysis of paraffin-embedded Human brain tissue using AP11940A performed on the Leica® BOND RXm. Tissue was fixed with formaldehyde at room temperature, antigen retrieval was by heat mediation with a EDTA buffer (pH9. 0). Samples were incubated with primary antibody(1:2000) for 1 hours at room temperature. A undiluted biotinylated CRF Anti-Polyvalent HRP Polymer antibody was used as the secondary antibody.
    detail
  • IF - TUBB2B Antibody (N-term) AP11940a
    Confocal immunofluorescent analysis of TUBB2B Antibody (N-term)(Cat#AP11940a) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF, IHC-P-Leica, E
Primary Accession Q9BVA1
Other Accession P02554, P13602, P32882, Q3KRE8, Q9CWF2, Q6B856, P85108, Q7TMM9, Q4R5B3, Q13885, P09203, NP_821080.1
Reactivity Human, Mouse, Rat
Predicted Chicken, Monkey, Bovine, Xenopus, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 49953 Da
Antigen Region 12-39 aa
Additional Information
Gene ID 347733
Other Names Tubulin beta-2B chain, TUBB2B
Target/Specificity This TUBB2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human TUBB2B.
Dilution WB~~1:4000
IHC-P-Leica~~1:2000
IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTUBB2B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TUBB2B
Function Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:23001566, PubMed:26732629, PubMed:28013290). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910).
Cellular Location Cytoplasm, cytoskeleton
Tissue Location High expression in brain.
Research Areas
Citations (0)
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Background

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq].

References

Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)
Jaglin, X.H., et al. Nat. Genet. 41(6):746-752(2009)
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
Cucchiarelli, V., et al. Cell Motil. Cytoskeleton 65(8):675-685(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)

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$ 365.00
$ 140.00
Cat# AP11940a
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