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TBB1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9H4B7 |
| Other Accession | NP_110400.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50327 Da |
| Antigen Region | 4-31 aa |
| Gene ID | 81027 |
|---|---|
| Other Names | Tubulin beta-1 chain, TUBB1 |
| Target/Specificity | This TBB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-31 amino acids from the N-terminal region of human TBB1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TBB1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TUBB1 |
|---|---|
| Function | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. |
| Cellular Location | Cytoplasm, cytoskeleton |
| Tissue Location | Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.
References
Anton, A.I., et al. Ann. Hematol. 89(11):1147-1154(2010)
Yin, S., et al. Mol. Cancer Ther. 9(2):327-335(2010)
Xu, W., et al. Mol. Cancer Ther. 8(12):3318-3330(2009)
Joe, P.A., et al. J. Biol. Chem. 284(7):4283-4291(2009)
Navarro-Nunez, L., et al. Thromb. Haemost. 100(6):1211-1213(2008)
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