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S100A1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P23297 |
| Other Accession | P02639, NP_006262.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 10546 Da |
| Antigen Region | 45-75 aa |
| Gene ID | 6271 |
|---|---|
| Other Names | Protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 calcium-binding protein A1, S100A1, S100A |
| Target/Specificity | This S100A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the C-terminal region of human S100A1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | S100A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | S100A1 |
|---|---|
| Synonyms | S100A |
| Function | Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). |
| Cellular Location | Cytoplasm. Sarcoplasmic reticulum. Mitochondrion {ECO:0000250|UniProtKB:P56565} |
| Tissue Location | Highly prevalent in heart (PubMed:12804600, PubMed:1384693). Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.
References
Marlatt, N.M., et al. Protein Expr. Purif. 73(1):58-64(2010)
van Dieck, J., et al. FEBS Lett. 584(15):3269-3274(2010)
Sviatoha, V., et al. Melanoma Res. 20(2):118-125(2010)
DeRycke, M.S., et al. Am. J. Clin. Pathol. 132(6):846-856(2009)
Yusenko, M.V., et al. Int. J. Biol. Sci. 5(6):517-527(2009)
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