KHSRP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IF, IHC-P, WB, E |
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Primary Accession | Q92945 |
Other Accession | Q99PF5, Q3U0V1, NP_003676.2 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 73115 Da |
Antigen Region | 470-498 aa |
Gene ID | 8570 |
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Other Names | Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2 |
Target/Specificity | This KHSRP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-498 amino acids from the Central region of human KHSRP. |
Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | KHSRP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KHSRP |
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Synonyms | FUBP2 |
Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue- specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. |
Cellular Location | Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. |
Tissue Location | Detected in neural and non-neural cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).
References
Michlewski, G., et al. Nat. Struct. Mol. Biol. 17(8):1011-1018(2010)
Bikkavilli, R.K., et al. J. Cell. Sci. 123 (PT 8), 1352-1362 (2010) :
Malz, M., et al. Hepatology 50(4):1130-1139(2009)
Trabucchi, M., et al. Nature 459(7249):1010-1014(2009)
Nechama, M., et al. BMC Cell Biol. 10, 70 (2009) :
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