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OTX2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P32243 |
| Other Accession | P80206, Q91981, Q6DKN2, Q91813, NP_068374.1, NP_758840.1 |
| Reactivity | Human |
| Predicted | Xenopus, Zebrafish, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31636 Da |
| Antigen Region | 261-289 aa |
| Gene ID | 5015 |
|---|---|
| Other Names | Homeobox protein OTX2, Orthodenticle homolog 2, OTX2 |
| Target/Specificity | This OTX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 amino acids from the C-terminal region of human OTX2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OTX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OTX2 |
|---|---|
| Function | Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Masuda, T., et al. J. Biol. Chem. 285(35):26933-26944(2010)
Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010)
Chung, C.Y., et al. Brain 133 (PT 7), 2022-2031 (2010) :
Ashkenazi-Hoffnung, L., et al. Hum. Genet. 127(6):721-729(2010)
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