SLC16A8 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O95907 |
Other Accession | NP_037488.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52319 Da |
Antigen Region | 466-493 aa |
Gene ID | 23539 |
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Other Names | Monocarboxylate transporter 3, MCT 3, Solute carrier family 16 member 8, SLC16A8, MCT3 |
Target/Specificity | This SLC16A8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-493 amino acids from the C-terminal region of human SLC16A8. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC16A8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC16A8 (HGNC:16270) |
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Synonyms | MCT3 |
Function | Probable retinal pigment epithelium (RPE)-specific proton- coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity). |
Cellular Location | Basolateral cell membrane; Multi-pass membrane protein. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (PubMed:21199217) Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000269|PubMed:21199217} |
Tissue Location | Retinal pigment epithelium. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM].
References
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Wilson, M.C., et al. J. Biol. Chem. 280(29):27213-27221(2005)
Halestrap, A.P., et al. Pflugers Arch. 447(5):619-628(2004)
Philp, N.J., et al. Invest. Ophthalmol. Vis. Sci. 44(4):1716-1721(2003)
Dunham, I., et al. Nature 402(6761):489-495(1999)
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