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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PRSS21 Antibody (Center)   

PRSS21 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PRSS21 Antibody (Center) AP11645c
    PRSS21 Antibody (Center) (Cat. #AP11645c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PRSS21 antibody detected the PRSS21 protein (arrow).
    detail
  • WB - PRSS21 Antibody (Center) AP11645c
    PRSS21 Antibody (Center) (Cat. #AP11645c) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the PRSS21 antibody detected the PRSS21 protein (arrow).
    detail
  • IHC-P - PRSS21 Antibody (Center) AP11645c
    PRSS21 Antibody (Center) (Cat. #AP11645c)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PRSS21 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
  • CITATIONS: 1
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y6M0
Other Accession NP_659206.1, NP_006790.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 34884 Da
Antigen Region 165-193 aa
Additional Information
Gene ID 10942
Other Names Testisin, 3421-, Eosinophil serine protease 1, ESP-1, Serine protease 21, PRSS21, ESP1, TEST1
Target/Specificity This PRSS21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human PRSS21.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRSS21 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRSS21
Synonyms ESP1, TEST1
Function Could regulate proteolytic events associated with testicular germ cell maturation.
Cellular Location Cell membrane; Lipid-anchor, GPI- anchor
Tissue Location Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes
Research Areas
Citations ( 0 )

Background

This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. It is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and it may be involved in progression of testicular tumors of germ cell origin. Alternative splicing of this gene results in three transcript variants encoding three different isoforms. [provided by RefSeq].

References

Yeom, S.Y., et al. FEBS Lett. 584(8):1469-1475(2010)
Netzel-Arnett, S., et al. Biol. Reprod. 81(5):921-932(2009)
Kempkensteffen, C., et al. J. Cancer Res. Clin. Oncol. 132(12):765-770(2006)
Manton, K.J., et al. Br. J. Cancer 92(4):760-769(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 365.00
$ 140.00
Cat# AP11645c
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