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PHOX2B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q99453 |
| Other Accession | O35690, Q62782, Q62066, O14813, NP_003915.2, G5EC89 |
| Reactivity | Mouse |
| Predicted | C.Elegans, Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31621 Da |
| Antigen Region | 104-130 aa |
| Gene ID | 8929 |
|---|---|
| Other Names | Paired mesoderm homeobox protein 2B, Neuroblastoma Phox, NBPhox, PHOX2B homeodomain protein, Paired-like homeobox 2B, PHOX2B, PMX2B |
| Target/Specificity | This PHOX2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-130 amino acids from the Central region of human PHOX2B. |
| Dilution | IF~~1:10~50 WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PHOX2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PHOX2B |
|---|---|
| Synonyms | PMX2B |
| Function | Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta- hydrolase and c-fos promoters, and of several enhancers including cAMP- response element and serum-response element. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Tissue Location | Expressed in neuroblastoma, brain and adrenal gland |
Provided below are standard protocols that you may find useful for product applications.
Background
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. [provided by RefSeq].
References
Rudzinski, E., et al. Pediatr. Dev. Pathol. 13(4):291-299(2010)
Janoueix-Lerosey, I., et al. Oncogene 29(11):1566-1579(2010)
Tu, E., et al. Hum. Pathol. 41(3):392-400(2010)
Arai, H., et al. J. Hum. Genet. 55(1):4-7(2010)
Dubreuil, V., et al. J. Neurosci. 29(47):14836-14846(2009)
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