HAUS3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q68CZ6 |
Other Accession | NP_078787.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 69650 Da |
Antigen Region | 372-400 aa |
Gene ID | 79441 |
---|---|
Other Names | HAUS augmin-like complex subunit 3, HAUS3, C4orf15 |
Target/Specificity | This HAUS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-400 amino acids from the Central region of human HAUS3. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | HAUS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HAUS3 |
---|---|
Synonyms | C4orf15 |
Function | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HAUS3 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).
References
Shah, S.P., et al. Nature 461(7265):809-813(2009)
Lawo, S., et al. Curr. Biol. 19(10):816-826(2009)
Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009)
Goshima, G., et al. J. Cell Biol. 181(3):421-429(2008)
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