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HMOX1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HMOX1 Antibody (Center) AP11240c
    Western blot analysis of HMOX1 (arrow) using rabbit polyclonal HMOX1 Antibody (Center) (Cat. #AP11240c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HMOX1 gene.
    detail
  • FC - HMOX1 Antibody (Center) AP11240c
    HMOX1 Antibody (Center) (Cat. #AP11240c) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession P09601
Other Accession NP_002124.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 32819 Da
Antigen Region 177-204 aa
Additional Information
Gene ID 3162
Other Names Heme oxygenase 1, HO-1, HMOX1, HO, HO1
Target/Specificity This HMOX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-204 amino acids from the Central region of human HMOX1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHMOX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMOX1
Synonyms HO, HO1
Function [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:11121422, PubMed:19556236, PubMed:7703255). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (PubMed:20055707).
Cellular Location Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side
Tissue Location Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)
Research Areas
Citations ( 0 )

Background

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

References

Wu, M.M., et al. Toxicol. Appl. Pharmacol. 248(3):226-233(2010)
Bolisetty, S., et al. J. Am. Soc. Nephrol. 21(10):1702-1712(2010)
Bao, W., et al. PLoS ONE 5 (8), E12371 (2010) :
Wu, M.M., et al. J. Biomed. Sci. 17, 70 (2010) :
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :

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$ 182.50
$ 70.00
Cat# AP11240c
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