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GPX3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P22352 |
| Other Accession | NP_002075 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25552 Da |
| Antigen Region | 93-123 aa |
| Gene ID | 2878 |
|---|---|
| Other Names | Glutathione peroxidase 3, GPx-3, GSHPx-3, Extracellular glutathione peroxidase, Plasma glutathione peroxidase, GPx-P, GSHPx-P, GPX3, GPXP |
| Target/Specificity | This GPX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-123 amino acids from the Central region of human GPX3. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPX3 (HGNC:4555) |
|---|---|
| Synonyms | GPXP |
| Function | Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. |
| Cellular Location | Secreted. |
| Tissue Location | Secreted in plasma. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
References
Wang, J.Y., et al. Clin. Chim. Acta 411 (19-20), 1432-1436 (2010) : Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Fullerton, J.M., et al. Bipolar Disord 12(5):550-556(2010) Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010) Mistry, H.D., et al. Placenta 31(5):401-408(2010)
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