TIEG Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, E |
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Primary Accession | Q13118 |
Other Accession | NP_005646 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52555 Da |
Antigen Region | 198-225 aa |
Gene ID | 7071 |
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Other Names | Krueppel-like factor 10, EGR-alpha, Transforming growth factor-beta-inducible early growth response protein 1, TGFB-inducible early growth response protein 1, TIEG-1, KLF10, TIEG, TIEG1 |
Target/Specificity | This TIEG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-225 amino acids from the Central region of human TIEG. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TIEG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KLF10 |
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Synonyms | TIEG, TIEG1 |
Function | Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:O89091}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'.
References
Kim, J., et al. Biochem. Biophys. Res. Commun. 401(3):412-416(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Subramaniam, M., et al. Biofactors 36(1):8-18(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
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