ECOP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96AW1 |
Other Accession | A6QNZ8, NP_110423.3 |
Reactivity | Mouse |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 19224 Da |
Antigen Region | 65-95 aa |
Gene ID | 81552 |
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Other Names | Vesicular, overexpressed in cancer, prosurvival protein 1, EGFR-coamplified and overexpressed protein, ECop, Glioblastoma-amplified secreted protein, Putative NF-kappa-B-activating protein 055N, VOPP1, ECOP, GASP |
Target/Specificity | This ECOP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-95 amino acids from the Central region of human ECOP. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ECOP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | VOPP1 (HGNC:34518) |
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Synonyms | ECOP, GASP |
Function | Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed (PubMed:15735698). May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor (PubMed:30285739). |
Cellular Location | Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions. |
Tissue Location | Widely expressed with highest levels in thymus and ovary. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
References
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Baras, A., et al. Oncogene 28(32):2919-2924(2009)
Chechlinska, M., et al. BMC Genomics 10, 261 (2009) :
Brem, H., et al. Mol. Med. 13 (1-2), 30-39 (2007) :
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