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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > GFRAL Antibody (C-term)
GFRAL Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q6UXV0 |
| Other Accession | NP_997293.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44518 Da |
| Antigen Region | 366-394 aa |
| Gene ID | 389400 |
|---|---|
| Other Names | GDNF family receptor alpha-like, GFRAL, C6orf144 |
| Target/Specificity | This GFRAL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-394 amino acids from the C-terminal region of human GFRAL. |
| Dilution | WB~~1:2000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GFRAL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GFRAL {ECO:0000303|PubMed:28846097, ECO:0000312|HGNC:HGNC:32789} |
|---|---|
| Function | Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin (PubMed:32661391). Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (PubMed:31535977, PubMed:32661391). Ligand- binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:32661391). |
| Cellular Location | Cell membrane; Single-pass membrane protein; Extracellular side |
| Tissue Location | Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :
Li, Z., et al. J. Neurochem. 95(2):361-376(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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$ 385.00
$ 150.00
Cat# AP11069B
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