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DMP4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8IXL6 |
| Other Accession | Q5MJS3, NP_064608.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66234 Da |
| Antigen Region | 443-471 aa |
| Gene ID | 56975 |
|---|---|
| Other Names | Extracellular serine/threonine protein kinase FAM20C, Dentin matrix protein 4, DMP-4, Golgi-enriched fraction casein kinase, GEF-CK, Protein FAM20C, FAM20C, DMP4 |
| Target/Specificity | This DMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 443-471 amino acids from the C-terminal region of human DMP4. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DMP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FAM20C (HGNC:22140) |
|---|---|
| Function | Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding (PubMed:29858230, PubMed:34349020). During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone (PubMed:32149426). This is critical to maintain ER proteostasis and reduce cell death under ER stress (PubMed:32149426). Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response (PubMed:32149426). Required for osteoblast differentiation and mineralization (PubMed:34349020). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1/OPN (PubMed:22582013, PubMed:25789606, PubMed:34349020). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). |
| Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Secreted. Endoplasmic reticulum. Note=Resides in the Golgi apparatus membrane and is secreted following propeptide cleavage (PubMed:34349020). Retained in the endoplasmic reticulum (ER) in response to ER stress where it phosphorylates P4HB (PubMed:32149426) |
| Tissue Location | Widely expressed.. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-binding protein which may play a role in dentin mineralization (By similarity).
References
Simpson, M.A., et al. Clin. Genet. 75(3):271-276(2009)
Simpson, M.A., et al. Am. J. Hum. Genet. 81(5):906-912(2007)
Hao, J., et al. J. Biol. Chem. 282(21):15357-15365(2007)
Nalbant, D., et al. BMC Genomics 6 (1), 11 (2005) :
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$ 365.00
$ 140.00
Cat# AP10983b
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