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UBTD1 Antibody (C-term G195)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9HAC8 |
| Other Accession | Q68FV8, Q91WB7, Q3ZBQ1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25938 Da |
| Antigen Region | 180-212 aa |
| Gene ID | 80019 |
|---|---|
| Other Names | Ubiquitin domain-containing protein 1, UBTD1 |
| Target/Specificity | This UBTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-212 amino acids from the C-terminal region of human UBTD1. |
| Dilution | WB~~1:1000 IHC-P~~1:50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBTD1 Antibody (C-term G195) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBTD1 |
|---|---|
| Function | May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. |
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Provided below are standard protocols that you may find useful for product applications.
Background
UBTD1 contains a ubiquitin domain, and has been demonstrated to bind to p53 in cells p53 is linked to the ubiquitination pathway through its transcriptional regulation of the four ubiquitin ligases, MDM2, COP1, Siah1b, and Pirh2. The role of UBTD1 has not been elucidated, however preliminary evidence indicates a potential role in p53 signaling.
References
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
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