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P5F1B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q06416 |
| Other Accession | Q9TSV5, P20263, Q01860, O97552, NP_001153014.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38588 Da |
| Antigen Region | 214-242 aa |
| Gene ID | 5462 |
|---|---|
| Other Names | Putative POU domain, class 5, transcription factor 1B, Oct4-pg1, Octamer-binding protein 3-like, Octamer-binding transcription factor 3-like, POU5F1B |
| Target/Specificity | This P5F1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-242 amino acids from the C-terminal region of human P5F1B. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P5F1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POU5F1B |
|---|---|
| Function | Shows weak transcriptional activator activity. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:18949397} |
| Tissue Location | Detected at the mRNA level in several cancer tissues (breast, uterine cervix, lung, thyroid gland, esophagus, colon, urinary bladder, and glioma), but absent in normal tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development.
References
Kastler, S., et al. Prostate 70(6):666-674(2010)
White, K.L., et al. Twin Res Hum Genet 13(1):43-56(2010)
Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)
Gudmundsson, J., et al. Nat. Genet. 41(10):1122-1126(2009)
Panagopoulos, I., et al. Oncol. Rep. 20(5):1029-1033(2008)
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