DPEP3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9H4B8 |
Other Accession | NP_001123230.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53687 Da |
Antigen Region | 391-420 aa |
Gene ID | 64180 |
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Other Names | Dipeptidase 3, DPEP3 |
Target/Specificity | This DPEP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human DPEP3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DPEP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DPEP3 |
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Function | Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (PubMed:32325220). |
Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9DA79}; Lipid- anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9DA79} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.
References
Sabatti, C., et al. Nat. Genet. 41(1):35-46(2009)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Habib, G.M., et al. FASEB J. 17(10):1313-1315(2003)
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