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RNT2 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RNT2 Antibody (N-term) AP10764a
    Western blot analysis of lysates from 293T cell line, human brain tissue lysate (from left to right), using RNT2 Antibody (N-term)(Cat. #AP10764a). AP10764a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
    detail
  • IHC-P - RNT2 Antibody (N-term) AP10764a
    RNT2 antibody (N-term) (Cat. #AP10764a) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RNT2 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O00584
Other Accession NP_003721.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 29481 Da
Antigen Region 25-55 aa
Additional Information
Gene ID 8635
Other Names Ribonuclease T2, 3127-, Ribonuclease 6, RNASET2, RNASE6PL
Target/Specificity This RNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 amino acids from the N-terminal region of human RNT2.
Dilution WB~~1:500-1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRNT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNASET2
Synonyms RNASE6PL
Function Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed:31778653). Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides (PubMed:31778653). In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed:31778653). Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed:28730546, PubMed:30184494). Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed:30385512).
Cellular Location Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Mitochondrion intermembrane space. Note=Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction.
Tissue Location Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
Research Areas
Citations ( 0 )

Background

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.

References

Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)
Quan, C., et al. Nat. Genet. 42(7):614-618(2010)
Liu, J., et al. J. Cell. Mol. Med. 14(5):1146-1155(2010)
Henneke, M., et al. Nat. Genet. 41(7):773-775(2009)
Monti, L., et al. Oncol. Res. 17(2):69-74(2008)

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$ 365.00
$ 140.00
Cat# AP10764a
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