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DEGS2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q6QHC5 |
| Other Accession | Q8R2F2, Q0II71, NP_996801.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37197 Da |
| Antigen Region | 261-290 aa |
| Gene ID | 123099 |
|---|---|
| Other Names | Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2, 1---, 114--, Degenerative spermatocyte homolog 2, DEGS2 (HGNC:20113), C14orf66 |
| Target/Specificity | This DEGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the C-terminal region of human DEGS2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DEGS2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DEGS2 (HGNC:20113) |
|---|---|
| Synonyms | C14orf66 |
| Function | Bifunctional enzyme which acts both as a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R2F2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8R2F2} |
| Tissue Location | Highly expressed in skin, intestine and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DEGS2 encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Mizutani, Y., et al. FEBS Lett. 563 (1-3), 93-97 (2004) :
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