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PAX7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P23759 |
| Other Accession | P47239, NP_001128726.1, NP_039236.1, NP_002575.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55119 Da |
| Antigen Region | 410-437 aa |
| Gene ID | 5081 |
|---|---|
| Other Names | Paired box protein Pax-7, HuP1, PAX7, HUP1 |
| Target/Specificity | This PAX7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-437 amino acids from the C-terminal region of human PAX7. |
| Dilution | WB~~1:2000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAX7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAX7 |
|---|---|
| Synonyms | HUP1 |
| Function | Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P47239}. |
Provided below are standard protocols that you may find useful for product applications.
Background
PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Williamson, D., et al. J. Clin. Oncol. 28(13):2151-2158(2010)
Xynos, A., et al. Stem Cells 28(5):965-973(2010)
Edwards, T.L., et al. Ann. Hum. Genet. 74(2):97-109(2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
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