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CYP2A7 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P20853 |
| Other Accession | Q05556, Q05555, P11509, P20852, P15392, P20812, NP_085079.2 |
| Reactivity | Human |
| Predicted | Rat, Mouse, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56425 Da |
| Antigen Region | 121-148 aa |
| Gene ID | 1549 |
|---|---|
| Other Names | Cytochrome P450 2A7, CYPIIA7, Cytochrome P450 IIA4, CYP2A7 |
| Target/Specificity | This CYP2A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-148 amino acids from the Central region of human CYP2A7. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CYP2A7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYP2A7 |
|---|---|
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
CYP2A7 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. CYP2A7, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
References
Fukami, T., et al. Pharmacogenomics J. 6(6):401-412(2006) Nelson, D.R., et al. Pharmacogenetics 14(1):1-18(2004) Oscarson, M., et al. Hum. Mutat. 20(4):275-283(2002) Godoy, W., et al. Carcinogenesis 23(4):611-616(2002) Koskela, S., et al. Biochem. Pharmacol. 57(12):1407-1413(1999)
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