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CTSA Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | P10619 |
| Other Accession | NP_001161066.1, NP_000299.2, NP_001121167.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54466 Da |
| Antigen Region | 18-45 aa |
| Gene ID | 5476 |
|---|---|
| Other Names | Lysosomal protective protein, Carboxypeptidase C, Carboxypeptidase L, Cathepsin A, Protective protein cathepsin A, PPCA, Protective protein for beta-galactosidase, Lysosomal protective protein 32 kDa chain, Lysosomal protective protein 20 kDa chain, CTSA, PPGB |
| Target/Specificity | This CTSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human CTSA. |
| Dilution | WB~~1:2000 IHC-P-Leica~~1:500 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTSA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTSA |
|---|---|
| Synonyms | PPGB |
| Function | Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. |
| Cellular Location | Lysosome. |
Provided below are standard protocols that you may find useful for product applications.
Background
CTSA encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis.
References
Reich, M., et al. Immunol. Lett. 128(2):143-147(2010)
Bonten, E.J., et al. J. Biol. Chem. 284(41):28430-28441(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Tatano, Y., et al. J. Med. Invest. 53 (1-2), 103-112 (2006) :
Lewandrowski, U., et al. Mol. Cell Proteomics 5(2):226-233(2006)
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