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JMJD2A Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O75164 |
| Other Accession | NP_055478 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 120662 Da |
| Antigen Region | 527-559 aa |
| Gene ID | 9682 |
|---|---|
| Other Names | Lysine-specific demethylase 4A, 11411-, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677 |
| Target/Specificity | This JMJD2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-559 amino acids from the N-terminal region of human JMJD2A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | JMJD2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDM4A |
|---|---|
| Synonyms | JHDM3A, JMJD2, JMJD2A, KIAA0677 |
| Function | Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168, PubMed:21768309). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779} |
| Tissue Location | Ubiquitous.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
References
Gray S.G., Iglesias A.H.J. Biol. Chem. 280:28507-28518(2005)
Zhang D., Yoon H.-G.Mol. Cell. Biol. 25:6404-6414(2005)
Whetstine J.R., Nottke A.Cell 125:467-481(2006)
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