ATPBD3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q7Z7A3 |
Other Accession | Q0VC66, NP_660275.2 |
Reactivity | Human, Mouse |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 36450 Da |
Antigen Region | 208-236 aa |
Gene ID | 90353 |
---|---|
Other Names | Cytoplasmic tRNA 2-thiolation protein 1 {ECO:0000255|HAMAP-Rule:MF_03053}, 277- {ECO:0000255|HAMAP-Rule:MF_03053}, ATP-binding domain-containing protein 3 {ECO:0000255|HAMAP-Rule:MF_03053}, Cancer-associated gene protein, Cytoplasmic tRNA adenylyltransferase 1 {ECO:0000255|HAMAP-Rule:MF_03053}, CTU1 {ECO:0000255|HAMAP-Rule:MF_03053} |
Target/Specificity | This ATPBD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-236 amino acids from the Central region of human ATPBD3. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ATPBD3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CTU1 {ECO:0000255|HAMAP-Rule:MF_03053} |
---|---|
Function | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. |
Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
References
Schlieker, C.D., et al. Proc. Natl. Acad. Sci. U.S.A. 105(47):18255-18260(2008)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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