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> home > Products > Primary Antibodies > Antibody Collections > Mitochondrion > TFB2M Antibody (C-term)
TFB2M Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9H5Q4 |
| Other Accession | NP_071761.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45349 Da |
| Antigen Region | 368-396 aa |
| Gene ID | 64216 |
|---|---|
| Other Names | Dimethyladenosine transferase 2, mitochondrial, 211-, Hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, h-mtTFB, h-mtTFB2, hTFB2M, mtTFB2, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, TFB2M, NS5ATP5 |
| Target/Specificity | This TFB2M antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human TFB2M. |
| Dilution | WB~~1:2000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TFB2M Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TFB2M (HGNC:18559) |
|---|---|
| Synonyms | NS5ATP5 |
| Function | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:12068295, PubMed:15526033, PubMed:20410300, PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non- template strand (PubMed:15526033, PubMed:29149603). Stimulates transcription independently of the methyltransferase activity (PubMed:12897151). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Ubiquitously expressed. |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Litonin, D., et al. J. Biol. Chem. 285(24):18129-18133(2010)
Norrbom, J., et al. Acta Physiol (Oxf) 198(1):71-79(2010)
Fukuoh, A., et al. Genes Cells 14(8):1029-1042(2009)
Cotney, J., et al. Hum. Mol. Genet. 18(14):2670-2682(2009)
Alonso-Montes, C., et al. Dis. Markers 25(3):131-139(2008)
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$ 192.50
$ 75.00
Cat# AP10145b
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