BCA3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NQ31 |
Other Accession | NP_065693.2 |
Reactivity | Human, Hamster, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 23114 Da |
Antigen Region | 54-83 aa |
Gene ID | 56672 |
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Other Names | A-kinase-interacting protein 1, Breast cancer-associated gene 3 protein, PKA-interacting protein, Proline-rich protein BCA3, AKIP1, BCA3, C11orf17 |
Target/Specificity | This BCA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human BCA3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BCA3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AKIP1 |
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Synonyms | BCA3, C11orf17 |
Function | Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. |
Cellular Location | Nucleus. Note=Locates to punctate spots |
Tissue Location | Expressed at high levels in adult heart and at lower levels in brain, testis, ovary and skeletal muscle. Up-regulated in some breast cancer cell lines. Isoform 1 and isoform 3 are expressed in fetal brain. |
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Provided below are standard protocols that you may find useful for product applications.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gao, N., et al. J. Biol. Chem. 285(36):28097-28104(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Gao, N., et al. J. Biol. Chem. 283(12):7834-7843(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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