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PD1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | Q15116 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 3E12A10 |
| Isotype | Mouse IgG2a |
| Calculated MW | 31.6KD |
| Immunogen | Purified recombinant fragment of human PD1 (AA: extra 21-170) expressed in HEK293 cells. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 5133 |
|---|---|
| Other Names | PDCD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1 |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 ICC~~ 1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PD1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDCD1 {ECO:0000303|PubMed:7851902, ECO:0000312|HGNC:HGNC:8760} |
|---|---|
| Function | Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.PLoS One. 2016 Jul 26;11(7):e0159383.2.Tumour Biol. 2016 Jun;37(6):7507-14.
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$ 385.00
Cat# AO2749a
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