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FOLR1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | P15328 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2G5C12 |
| Isotype | Mouse IgG2a |
| Calculated MW | 29.8kDa |
| Immunogen | Purified recombinant fragment of human FOLR1 (AA: 41-227) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 2348 |
|---|---|
| Other Names | FBP; FOLR |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 ICC~~ 1/100 - 1/500 IHC~~ 1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FOLR1 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOLR1 |
|---|---|
| Synonyms | FOLR |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor Apical cell membrane; Lipid-anchor, GPI- anchor Basolateral cell membrane; Lipid-anchor, GPI-like-anchor. Secreted Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane |
| Tissue Location | Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Biosens Bioelectron. 2016 Apr 15;78:147-53.2.PLoS One. 2015 Mar 27;10(3):e0122209.
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$ 385.00
Cat# AO2726a
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