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FOLR1

Purified Mouse Monoclonal Antibody

     
  • E - FOLR1 AO2725a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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  • WB - FOLR1 AO2725a
    Figure 2:Western blot analysis using FOLR1 mAb against human FOLR1 (AA: 41-227) recombinant protein. (Expected MW is 48 kDa)
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  • WB - FOLR1 AO2725a
    Figure 3:Western blot analysis using FOLR1 mAb against HEK293 (1) and FOLR1 (AA: 41-227)-hIgGFc transfected HEK293 (2) cell lysate.
    detail
  •  - FOLR1 AO2725a
    Figure 4:Flow cytometric analysis of Hela cells using FOLR1 mouse mAb (green) and negative control (red).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession P15328
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 3G12B7
Isotype Mouse IgG1
Calculated MW 29.8kDa
Immunogen Purified recombinant fragment of human FOLR1 (AA: 41-227) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 2348
Other Names FBP; FOLR
Dilution E~~ 1/10000
WB~~ 1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOLR1 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOLR1
Synonyms FOLR
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Has high affinity for folate and folic acid analogs at neutral pH (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728). Required for normal embryonic development and normal cell proliferation (By similarity).
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor Apical cell membrane; Lipid-anchor, GPI- anchor Basolateral cell membrane; Lipid-anchor, GPI-like-anchor. Secreted Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane
Tissue Location Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
Citations (0)
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References

1.Biosens Bioelectron. 2016 Apr 15;78:147-53.2.PLoS One. 2015 Mar 27;10(3):e0122209.

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$ 385.00
Cat# AO2725a
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