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CD191
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | P32246 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 8E10G6 |
| Isotype | Mouse IgG1 |
| Calculated MW | 41.2kDa |
| Immunogen | Purified recombinant fragment of human CD191 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 1230 |
|---|---|
| Other Names | CCR1; CKR1; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1 |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD191 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCR1 |
|---|---|
| Synonyms | CMKBR1, CMKR1, SCYAR1 |
| Function | Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (PubMed:15905581). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4 (By similarity). Mediates also monocyte migration upon CXCL4 binding (PubMed:29930254). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed in different hematopoietic cells. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.Histol Histopathol. 2014 Sep;29(9):1153-60.2.Am J Clin Pathol. 2010 Mar;133(3):473-83.
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$ 385.00
Cat# AO2723a
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