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CD152

Purified Mouse Monoclonal Antibody

     
  • E - CD152 AO2681a
    Figure 4:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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  • WB - CD152 AO2681a
    Figure 2:Western blot analysis using CD152 mAb against human CD152 (AA: extra 36-161) recombinant protein. (Expected MW is 39.5 kDa)
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  • WB - CD152 AO2681a
    Figure 3:Western blot analysis using CD152 mAb against HEK293 (1) and CD152 (AA: extra 36-161)-hIgGFc transfected HEK293 (2) cell lysate.
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  •  - CD152 AO2681a
    Figure 4:Flow cytometric analysis of Ramos cells using CD152 mouse mAb (green) and negative control (red).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession P16410
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8B3F8
Isotype Mouse IgG1
Calculated MW 24.6kDa
Immunogen Purified recombinant fragment of human CD152 (AA: extra 36-161) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 1493
Other Names CTLA4; CD; GSE; GRD4; ALPS5; CTLA-4; IDDM12; CELIAC3
Dilution E~~ 1/10000
WB~~ 1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD152 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTLA4
Synonyms CD152
Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization
Tissue Location Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Research Areas
Citations (0)
citation

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References

1.Asian Pac J Cancer Prev. 2016;17(8):3785-91.2.Eur J Cancer. 2015 Nov;51(17):2689-97.

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$ 385.00
Cat# AO2681a
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