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CD195
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | P51681 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 6G11D1 |
| Isotype | Mouse IgG1 |
| Calculated MW | 40.5kDa |
| Immunogen | Purified recombinant fragment of human CD195 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 1234 |
|---|---|
| Other Names | CCR5; CKR5; CCR-5; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5 |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 IHC~~ 1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CD195 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCR5 (HGNC:1606) |
|---|---|
| Synonyms | CMKBR5 |
| Function | Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung. |
Research Areas
- Primary Antibodies
- Cancer
- Cardiovascular
- Immunology
- Microbiology
- Neuroscience
- Signal Transduction
- Antibody Collections
- GPCR Antibodies
- Druggable G protein-coupled receptors (GPCRs)
- Host cell receptor for virus entry
- Host-virus interaction
- Immune system process
- Chemokine receptor family
- Chemokine signaling
- Inflammation mediated by chemokine and cytokine signaling
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.J Leukoc Biol. 2015 Jul;98(1):59-71. 2.J Gen Virol. 2015 Aug;96(8):2074-8.
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$ 385.00
Cat# AO2655a
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