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HAVCR1

Purified Mouse Monoclonal Antibody

     
  • E - HAVCR1 AO2575a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
    detail
  • WB - HAVCR1 AO2575a
    Figure 2:Western blot analysis using HAVCR1 mAb against human HAVCR1 (AA: 70-290) recombinant protein. (Expected MW is 37 kDa)
    detail
  • WB - HAVCR1 AO2575a
    Figure 3:Western blot analysis using HAVCR1 mAb against HEK293 (1) and HAVCR1 (AA: 70-290)-hIgGFc transfected HEK293 (2) cell lysate.
    detail
  • WB - HAVCR1 AO2575a
    Figure 4:Western blot analysis using HAVCR1 mouse mAb against NIH/3T3 (1), HEK293 (2), Hela (3), Raw264.7 (4), Jurkat (5), and PC-2 (6) cell lysate.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession Q96D42
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 3D9F5
Isotype Mouse IgG1
Calculated MW 38.7kDa
Immunogen Purified recombinant fragment of human HAVCR1 (AA: 70-290) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 26762
Other Names TIM; KIM1; TIM1; CD365; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1
Dilution E~~ 1/10000
WB~~ 1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHAVCR1 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HAVCR1
Synonyms KIM1, TIM1, TIMD1
Function Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P- selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Regulates also expression of various anti- inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (PubMed:17471468).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
Research Areas
Citations (0)
citation

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References

1.Biomed Res Int. 2015;2015:854070. 2.Pediatr Res. 2015 Oct;78(4):430-5.

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$ 385.00
Cat# AO2575a
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