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GRM7
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | Q14831 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 7G8D3 |
| Isotype | Mouse IgG1 |
| Calculated MW | 102.3kDa |
| Immunogen | Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 2917 |
|---|---|
| Other Names | GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87 |
| Dilution | E~~ 1/10000 WB~~ 1/300 - 1/800 ICC~~ 1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GRM7 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRM7 |
|---|---|
| Synonyms | GPRC1G, MGLUR7 |
| Function | G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
1.Psychiatr Genet. 2014 Dec;24(6):281-2.2.Life Sci. 2013 Feb 7;92(2):149-53.
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