TFAP2B
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, E |
---|---|
Primary Accession | Q92481 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 6F7G1 |
Isotype | Mouse IgG2b |
Calculated MW | 50.5kDa |
Immunogen | Purified recombinant fragment of human TFAP2B (AA: 84-193) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 7021 |
---|---|
Other Names | PDA2; AP-2B; AP2-B |
Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TFAP2B is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TFAP2B |
---|---|
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q61313}. Note=In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. {ECO:0000250|UniProtKB:Q61313} |
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Provided below are standard protocols that you may find useful for product applications.
References
1.Eur J Gynaecol Oncol. 2015;36(3):268-73.2.Hum Hered. 2013;75(2-4):213-9.
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