AEBP2
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, E |
---|---|
Primary Accession | Q6ZN18 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 3E3C10 |
Isotype | Mouse IgG1 |
Calculated MW | 54.5kDa |
Immunogen | Purified recombinant fragment of human AEBP2 (AA: 358-495) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Gene ID | 121536 |
---|---|
Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 ICC~~ 1/100 - 1/500 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | AEBP2 is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AEBP2 |
---|---|
Function | Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:29499137, PubMed:31959557). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). |
Cellular Location | Nucleus. Note=Localizes to chromatin as part of the PRC2 complex |
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Provided below are standard protocols that you may find useful for product applications.
References
1.PLoS One. 2015 Apr 27;10(4):e0126966.2.Elife. 2012 Oct 30;1:e00005.
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