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NAA10

Purified Mouse Monoclonal Antibody

     
  • E - NAA10 AO2506a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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  • WB - NAA10 AO2506a
    Figure 2:Western blot analysis using NAA10 mAb against human NAA10 (AA: 111-235) recombinant protein. (Expected MW is 47.2 kDa)
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  • WB - NAA10 AO2506a
    Figure 3:Western blot analysis using NAA10 mAb against HEK293 (1) and NAA10 (AA: 111-235)-hIgGFc transfected HEK293 (2) cell lysate.
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  • WB - NAA10 AO2506a
    Figure 4:Western blot analysis using NAA10 mouse mAb against COS7 (1), HEK293 (2), HL-60 (3), MCF-7 (4), Hela (5), NIH/3T3 (6), and C2C12 (7) cell lysate.
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  •  - NAA10 AO2506a
    Figure 6:Flow cytometric analysis of SMMC-7721 cells using NAA10 mouse mAb (green) and negative control (red).
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  • ICC - NAA10 AO2506a
    Figure 5:Immunofluorescence analysis of Hela cells using NAA10 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession P41227
Reactivity Human, Mouse, Monkey
Host Mouse
Clonality Monoclonal
Clone Names 3G3B9
Isotype Mouse IgG1
Calculated MW 26.5kDa
Immunogen Purified recombinant fragment of human NAA10 (AA: 111-235) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 8260
Other Names TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; DXS707; MCOPS1
Dilution E~~ 1/10000
WB~~ 1/500 - 1/2000
ICC~~ 1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNAA10 is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NAA10
Synonyms ARD1, ARD1A, TE2
Function Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19420222, PubMed:19826488, PubMed:20145209, PubMed:20154145, PubMed:25489052, PubMed:27708256, PubMed:29754825, PubMed:32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acetylates HIST1H4A (PubMed:29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821).
Cellular Location Cytoplasm. Nucleus. Note=Also present in the free cytosolic and cytoskeleton-bound polysomes.
Tissue Location Ubiquitous..
Research Areas
Citations (0)
citation

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References

1.Gene. 2015 Aug 10;567(2):103-31.2.PLoS One. 2014 Aug 18;9(8):e105185.

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$ 385.00
Cat# AO2506a
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