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ASH2L

Purified Mouse Monoclonal Antibody

     
  • E - ASH2L AO2500a
    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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  • WB - ASH2L AO2500a
    Figure 2:Western blot analysis using ASH2L mAb against human ASH2L (AA: 493-628) recombinant protein. (Expected MW is 41.6 kDa)
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  • WB - ASH2L AO2500a
    Figure 3:Western blot analysis using ASH2L mAb against HEK293 (1) and ASH2L (AA: 493-628)-hIgGFc transfected HEK293 (2) cell lysate.
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  • IHC - ASH2L AO2500a
    Figure 4:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using ASH2L mouse mAb with DAB staining.
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  • IHC - ASH2L AO2500a
    Figure 5:Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ASH2L mouse mAb with DAB staining.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, ICC, E
Primary Accession Q9UBL3
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6B10H10
Isotype Mouse IgG1
Calculated MW 68.7kDa
Immunogen Purified recombinant fragment of human ASH2L (AA: 493-628) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 9070
Other Names ASH2; Bre2; ASH2L1; ASH2L2
Dilution E~~ 1/10000
WB~~ 1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsASH2L is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASH2L
Synonyms ASH2L1
Function Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes.
Citations (0)
citation

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References

1.Mol Cell. 2013 Mar 28;49(6):1108-20. 2.Nat Struct Mol Biol. 2011 Jun 5;18(7):857-9.

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$ 385.00
Cat# AO2500a
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