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TFAP2A
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC, E |
|---|---|
| Primary Accession | P05549 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2H9B5 |
| Isotype | Mouse IgG1 |
| Calculated MW | 48kDa |
| Immunogen | Purified recombinant fragment of human TFAP2A (AA: 105-211) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Gene ID | 7020 |
|---|---|
| Other Names | AP-2; BOFS; AP2TF; TFAP2; AP-2alpha |
| Dilution | E~~ 1/10000 WB~~ 1/500 - 1/2000 ICC~~ 1/200 - 1/1000 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TFAP2A is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TFAP2A |
|---|---|
| Synonyms | AP2TF, TFAP2 |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
1.Int J Clin Exp Pathol. 2014 Nov 26;7(12):8666-74.2.Hum Pathol. 2012 Nov;43(11):1866-74.
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