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Mouse Monoclonal Antibody to ASH2L

Purified Mouse Monoclonal Antibody

     
  • E - Mouse Monoclonal Antibody to ASH2L AO2494a
    Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
    detail
  • WB - Mouse Monoclonal Antibody to ASH2L AO2494a
    Western blot analysis using ASH2L mAb against human ASH2L (AA: 493-628) recombinant protein. (Expected MW is 41.6 kDa)
    detail
  • WB - Mouse Monoclonal Antibody to ASH2L AO2494a
    Western blot analysis using ASH2L mAb against HEK293 (1) and ASH2L (AA: 493-628)-hIgGFc transfected HEK293 (2) cell lysate.
    detail
  • WB - Mouse Monoclonal Antibody to ASH2L AO2494a
    Western blot analysis using ASH2L mouse mAb against K562 (1) and F9 (2) cell lysate.
    detail
  • FC - Mouse Monoclonal Antibody to ASH2L AO2494a
    Flow cytometric analysis of K562 cells using ASH2L mouse mAb (green) and negative control (red).
    detail
  • IHC - Mouse Monoclonal Antibody to ASH2L AO2494a
    Immunohistochemical analysis of paraffin-embedded colon cancer tissues using ASH2L mouse mAb with DAB staining.
    detail
  • IHC - Mouse Monoclonal Antibody to ASH2L AO2494a
    Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using ASH2L mouse mAb with DAB staining.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC, E
Primary Accession Q9UBL3
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 6F6B9
Isotype Mouse IgG1
Calculated MW 68.7kDa
Description ASH2L (Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila)) is a Protein Coding gene. Diseases associated with ASH2L include Kabuki Syndrome 1. Among its related pathways are Developmental Biology and Signaling by Wnt. GO annotations related to this gene include transcription regulatory region DNA binding and histone methyltransferase activity (H3-K4 specific).;
Immunogen Purified recombinant fragment of human ASH2L (AA: 493-628) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Application Note ELISA: 1/10000
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
FCM: 1/200 - 1/400
Additional Information
Gene ID 9070
Other Names ASH2; Bre2; ASH2L1; ASH2L2
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Monoclonal Antibody to ASH2L is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASH2L
Synonyms ASH2L1
Function Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes.
Research Areas
Citations (0)
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References

1.Mol Cell. 2013 Mar 28;49(6):1108-20. ; 2.Nat Struct Mol Biol. 2006 Sep;13(9):852-4. ;

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$ 385.00
Cat# AO2494a
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