Mouse Monoclonal Antibody to ADAMTS1
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, E |
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Primary Accession | Q9UHI8 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 1C12E6 |
Isotype | Mouse IgG1 |
Calculated MW | 105.4kDa |
Description | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.; |
Immunogen | Purified recombinant fragment of human ADAMTS1 (AA: 858-960) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 FCM: 1/200 - 1/400 |
Gene ID | 9510 |
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Other Names | C3-C5; METH1 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Monoclonal Antibody to ADAMTS1 is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ADAMTS1 |
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Synonyms | KIAA1346, METH1 |
Function | Cleaves aggrecan, a cartilage proteoglycan, at the '1938- Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
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Provided below are standard protocols that you may find useful for product applications.
References
1.Mol Cancer. 2013 Jan 5;12:2. ; 2.Cancer Sci. 2012 Oct;103(10):1889-97.;
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