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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Mouse Monoclonal Antibody to ADRB2
Mouse Monoclonal Antibody to ADRB2
Purified Mouse Monoclonal Antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | P07550 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 4A6C9 |
| Isotype | Mouse IgG1 |
| Calculated MW | 46.5kDa |
| Description | This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.; |
| Immunogen | Purified recombinant fragment of human ADRB2 (AA: 302-413) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
| Application Note | ELISA: 1/10000 WB: 1/500 - 1/2000 FCM: 1/200 - 1/400 |
| Gene ID | 154 |
|---|---|
| Other Names | BAR; B2AR; ADRBR; ADRB2R; BETA2AR |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Monoclonal Antibody to ADRB2 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADRB2 |
|---|---|
| Synonyms | ADRB2R, B2AR |
| Function | Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325) Activated receptors are also detected within the Golgi apparatus (PubMed:27481942). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
1.World J Gastroenterol. 2015 Jun 21;21(23):7191-6. ; 2.Adv Exp Med Biol. 2015;842:247-61.;
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$ 385.00
Cat# AO2465a
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